Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist
نویسندگان
چکیده
منابع مشابه
AM281, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit
Objective(s) Cannabinoids have been implicated in memory deficit. We examined the effect of AM281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. Materials and Methods Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously...
متن کاملam281, cannabinoid antagonist/inverse agonist, ameliorates scopolamine-induced cognitive deficit
objective(s) cannabinoids have been implicated in memory deficit. we examined the effect of am281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. materials and methods object recognition task was used to evaluate memory in mice. exploration time in the first and the second trial was recorded. the differences in exploration between a previously se...
متن کاملAM281, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit
OBJECTIVES Cannabinoids have been implicated in memory deficit. We examined the effect of AM281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. MATERIALS AND METHODS Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously see...
متن کاملthe effect of am281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice
abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of am281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. cognition was evaluated by using the object recognition task. the novel object recogni...
متن کاملJPET #201962 1 Title Page Cannabinoid Discrimination and Antagonism by CB1 Neutral and Inverse Agonist Antagonists
CB1 inverse agonists (e.g., rimonabant) have been reported to produce adverse effects including nausea, emesis, and anhedonia that limit their clinical applications. Recent laboratory studies suggest that the effects of CB1 neutral antagonists differ from those of such inverse agonists, raising the possibility of improved clinical utility. However, little is known regarding the antagonist prope...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2015
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-015-3907-0